Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis
نویسندگان
چکیده
منابع مشابه
Psoriasis and Atopic Dermatitis
Psoriasis and atopic dermatitis are common, chronic inflammatory skin diseases. We discuss several aspects of these disorders, including: risk factors; incidence and prevalence; the complex disease burden; and the comorbidities that increase the clinical significance of each disorder. We also focus on treatment management strategies and outline why individualized, patient-centered treatment reg...
متن کاملAryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis
Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other susceptibility genes, for example, Ovo-like 1 (OVOL1). Nonetheless, the relation between FLG and OVOL1 is unclear. Because aryl hydrocarbon receptor (AHR; a ligand-activated transcription factor), plays a role in FLG expression in keratinocytes, we...
متن کاملCoexistence of psoriasis and atopic dermatitis
Psoriasis is a recurrent inflammatory skin disease which affects around 2% of the population and is characterized by erythematous papules and plaques covered with silvery white scales. [1]. Atopic dermatitis (AD) is a common skin condition, particularly in children, regarded as one of the 50 most prevalent diseases worldwide [2]. Prevalence of AD in adult patients is around 1-3 % [3]. Patients ...
متن کاملTWEAK mediates inflammation in experimental atopic dermatitis and psoriasis
Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune responses, but some proteins might be critical to both diseases. Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in defective maintenance of AD-specific T helper type 2 (Th2) and psoriasis-specific Th17 cells in the skin, and impaired expression of disease-charac...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20215424